Article

Opposing roles for TGFβ- and BMP-signaling during nascent alveolar differentiation in the developing human lung

2023-05-05

Abstract excerpt

Alveolar type 2 (AT2) cells function as stem cells in the adult lung and aid in repair after injury. The current study aimed to understand the signaling events that control differentiation of this therapeutically relevant cell type during human development. Using lung explant and organoid models, we identified opposing effects of TGFβ- and BMP-signaling, where inhibition of TGFβ- and activation of BMP-signaling in...

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Literature Corpus work: b12fa7a5-9814-58e5-bd97-ed5f98e399b6
DOI: 10.1101/2023.05.05.539573

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