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Article

Culture conditions differentially regulate the inflammatory niche and cellular phenotype of tracheobronchial basal stem cells.

American journal of physiology. Lung cellular and molecular physiology - 1 Apr 2025

Murthy Shubha, Seabold Denise A, Gautam Lalit K, Caceres Adrian M, Sease Rosemary, Calvert Ben A, Busch Shana M, Neely Aaron, Marconett Crystal N, Ryan Amy L

Abstract excerpt

Bronchial epithelial cells derived from the tracheobronchial regions of human airways (HBECs) provide a valuable in vitro model for studying pathological mechanisms and evaluating therapeutics. This cell population comprises a mixed population of basal cells (BCs), the predominant stem cell in airways capable of both self-renewal and functional differentiation. Despite their potential for regenerative medicine,...

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Identifiers

PMID: 39982813
DOI: 10.1152/ajplung.00293.2024
PMCID: PMC12261264

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