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Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition

26 Nov 2020

Abstract excerpt

Alveologenesis is a developmental step involving the expansion of the lung surface area which is essential for gas exchange. The gas exchange process is mediated by alveolar type I (AT1) cells, which are known to be differentiated from alveolar type II (AT2) or bipotent cells. Due to the difficulty of isolating and culturing primary AT1 cells, the mechanism underlying their differentiation is not completely...

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PMID: 33241896
DOI: 10.1002/stem.3302

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