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Development of human alveolar epithelial cell models to study distal lung biology and disease

15 Jan 2022

Abstract excerpt

Many acute and chronic diseases affect the distal lung alveoli. Alveolar epithelial cell (AEC) lines are needed to better model these diseases. We used de-identified human remnant transplant lungs to develop a method to establish AEC lines. The lines grow well in 2-dimensional (2D) culture as epithelial monolayers expressing lung progenitor markers. In 3-dimensional (3D) culture with fibroblasts, Matrigel, and...

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PMID: 35169685
DOI: 10.1016/j.isci.2022.103780

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