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Article

Functional network phenotypes of mild behavioural impairment: cognitive effects moderated by amyloid.

Alzheimer's research & therapy - 10 Feb 2026

Ng Kok Pin, Chong Joanna Su Xian, Lussier Firoza, Therriault Joseph, Rahmouni Nesrine, Savard Melissa, Stevenson Jenna, Pascoal Tharick, Gauthier Serge, Rosa-Neto Pedro, Zhou Juan Helen

Abstract excerpt

BACKGROUND: Mild behavioural impairment (MBI) is a neurobehavioural syndrome that represents an at-risk state for incident cognitive decline. No study to date has systematically investigated whole-brain within- and between- network functional connectivity (FC) disruptions in MBI and their effects on cognitive performance in dementia-free individuals. Hence, we sought to evaluate the whole-brain functional network...

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Identifiers

PMID: 41668114
DOI: 10.1186/s13195-026-01980-2
PMCID: PMC12990541

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