Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia.

doi:10.1002/alz.12209

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2021

Tsvetanov Kamen A, Gazzina Stefano, Jones P Simon, van Swieten John, Borroni Barbara, Sanchez-Valle Raquel, Moreno Fermin, Laforce Robert, Graff Caroline, Synofzik Matthis, Galimberti Daniela, Masellis Mario, Tartaglia Maria Carmela, Finger Elizabeth, Vandenberghe Rik, de Mendonça Alexandre, Tagliavini Fabrizio, Santana Isabel, Ducharme Simon, Butler Chris, Gerhard Alexander, Danek Adrian, Levin Johannes, Otto Markus, Frisoni Giovanni, Ghidoni Roberta, Sorbi Sandro, Rohrer Jonathan D, Rowe James B

Abstract excerpt

INTRODUCTION: The presymptomatic phase of neurodegenerative disease can last many years, with sustained cognitive function despite progressive atrophy. We investigate this phenomenon in familial frontotemporal dementia (FTD). METHODS: We studied 121 presymptomatic FTD mutation carriers and 134 family members without mutations, using multivariate data-driven approach to link cognitive performance with both...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atrophy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to C9orf72 Protein

Share to Cognition

Share to Frontotemporal Dementia

Share to Internationality

Share to Magnetic Resonance Imaging

Share to Prodromal Symptoms

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 33215845
DOI: 10.1002/alz.12209
PMCID: PMC7611220

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia.PMID 33215845Read ↗

Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementiaSemantic proximity Read ↗

Frontoparietal network integrity supports cognitive function in pre-symptomatic frontotemporal dementia: Multimodal analysis of brain function, structure, and perfusion.Semantic proximity Read ↗

Cellular signatures of functional resilience in presymptomatic frontotemporal dementiaSemantic proximity Read ↗

Structural and functional connectivity in tau mutation carriers: from presymptomatic to symptomatic frontotemporal dementia.Semantic proximity Read ↗

Temporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementia.Semantic proximity Read ↗

Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia.Semantic proximity Read ↗

Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal dominant Alzheimer’s diseaseSemantic proximity Read ↗

Preferential degradation of cognitive networks differentiates Alzheimer’s disease from ageingSemantic proximity Read ↗

Resting-State Functional Connectivity Disruption as a Pathological Biomarker in Autosomal Dominant Alzheimer DiseaseSemantic proximity Read ↗

Disrupted dynamics of brain structure–function coupling link genetic risk of Alzheimer’s Disease and aging to cognitive decline in 34,067 adultsSemantic proximity Read ↗

Network degeneration and dysfunction in presymptomatic C9ORF72 expansion carriersSemantic proximity Read ↗

Functional network phenotypes of mild behavioural impairment: cognitive effects moderated by amyloid.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.