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Article

White matter dysfunction in Alzheimer’s disease is associated with disease-related transcriptomic signatures

28 May 2025

Abstract excerpt

While anatomical white matter (WM) alterations in Alzheimer's disease (AD) are well-established, functional WM dysregulation remains rarely investigated. The current study examines WM functional connectivity and network properties alterations in AD and mild cognitive impairment (MCI) and further describes their spatially correlated genes. AD and MCI shared decreased functional connectivity, clustering...

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PMID: 40437109
DOI: 10.1038/s42003-025-08177-7

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