Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.

doi:10.1002/alz.71638

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Article

Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2026

Li Yating, Wang Dong, Zhou Rongshen, Yan Shaozhen, Wang Dawei, Wei Yongbin, Yao Hongxiang, Zhou Bo, Lu Jie, Wang Pan, Liao Zhengluan, Han Ying, Zhang Xi, Zhang Yihe, Liu Yong, Zhao Kun

Abstract excerpt

INTRODUCTION: Mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease (AD), shows pronounced clinical heterogeneity poorly explained by pathology burden, representing a gap complicating prognosis. As the brain operates as a complex network for information integration, we hypothesized that connectome architecture mediates the link between AD pathology and clinical expression. METHODS: We...

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PMID: 42381349
DOI: 10.1002/alz.71638
PMCID: PMC13319412

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