Article
Frontoparietal network integrity supports cognitive function in pre-symptomatic frontotemporal dementia: Multimodal analysis of brain function, structure, and perfusion.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Dec 2024
Liu Xulin, Jones Peter Simon, Pasternak Maurice, Masellis Mario, Bouzigues Arabella, Russell Lucy L, Foster Phoebe H, Ferry-Bolder Eve, van Swieten John, Jiskoot Lize, Seelaar Harro, Sanchez-Valle Raquel, Laforce Robert, Graff Caroline, Galimberti Daniela, Vandenberghe Rik, de Mendonça Alexandre, Tiraboschi Pietro, Santana Isabel, Gerhard Alexander, Levin Johannes, Sorbi Sandro, Otto Markus, Pasquier Florence, Ducharme Simon, Butler Chris, Le Ber Isabelle, Finger Elizabeth, Tartaglia Maria Carmela, Synofzik Matthis, Moreno Fermin, Borroni Barbara, Rohrer Jonathan D, Tsvetanov Kamen A, Rowe James B
Abstract excerpt
INTRODUCTION: Genetic mutation carriers of frontotemporal dementia can remain cognitively well despite neurodegeneration. A better understanding of brain structural, perfusion, and functional patterns in the pre-symptomatic stage could inform accurate staging and potential mechanisms. METHODS: We included 207 pre-symptomatic genetic mutation carriers and 188 relatives without mutations. The gray matter volume,...
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