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Article

Retinal phenotype of APOB100 transgenic mice on a Western diet with human-like hyperlipidemia and cholesterol crystals in the retina and choroid.

Lab animal - 1 Mar 2026

El-Darzi Nicole, Dorweiler Tim F, Mast Natalia, Busik Julia, Pikuleva Irina A

Abstract excerpt

Drusen and subretinal drusenoid deposits, the pathognomonic lesions for age-related macular degeneration (AMD), are rich in cholesterol. Yet, AMD is not consistently linked to plasma lipids. Here wild-type and human apolipoprotein B100-expressing (APOB100) mice were put on a Western type of diet for 13 months and then assessed for plasma lipid profile, high-density lipoprotein (HDL) heterogeneity, status of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41663777
DOI: 10.1038/s41684-026-01693-x
PMCID: PMC12956585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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