Article
Characterizing the Retinal Phenotype in the High-Fat Diet and Western Diet Mouse Models of Prediabetes.
Cells - 18 Feb 2020
Asare-Bediako Bright, Noothi Sunil K, Li Calzi Sergio, Athmanathan Baskaran, Vieira Cristiano P, Adu-Agyeiwaah Yvonne, Dupont Mariana, Jones Bryce A, Wang Xiaoxin X, Chakraborty Dibyendu, Levi Moshe, Nagareddy Prabhakara R, Grant Maria B
Abstract excerpt
We sought to delineate the retinal features associated with the high-fat diet (HFD) mouse, a widely used model of obesity. C57BL/6 mice were fed either a high-fat (60% fat; HFD) or low-fat (10% fat; LFD) diet for up to 12 months. The effect of HFD on body weight and insulin resistance were measured. The retina was assessed by electroretinogram (ERG), fundus photography, permeability studies, and trypsin digests...
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