Article

Long-term Dietary Fat Intervention Affects Retinal Health in APOE Mice

2025-08-01

Abstract excerpt

The APOE genotype influences metabolic and neurodegenerative outcomes, with APOE4 carriers at higher risk for Alzheimer’s disease (AD) and metabolic dysfunction. This study examines how long-term dietary interventions affect systemic metabolism, retinal structure/ function in APOE3 -knock-in (KI, neutral for AD) and APOE4 -KI mice. Humanized APOE3 and APOE4 -KI mice received either a control diet (CD) or a W...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a6ce6f3d-fd37-578b-b41e-cd1f2bb1afdf
DOI: 10.1101/2025.07.30.667671

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Long-term Dietary Fat Intervention Affects Retinal Health in APOE MiceDOI 10.1101/2025.07.30.667671Read

Characterizing the Retinal Phenotype in the High-Fat Diet and Western Diet Mouse Models of Prediabetes.Semantic proximity Read

Studies of ApoD-/- and ApoD-/-ApoE-/- mice uncover the APOD significance for retinal metabolism, function, and status of chorioretinal blood vessels.Semantic proximity Read

Impacts of high fat diet on ocular outcomes in rodent models of visual diseaseSemantic proximity Read

Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration.Semantic proximity Read

Effects of the ApoE genotype on cognitive function in aging mice fed with a high-fat diet and the protective potential of n-3 polyunsaturated fatty acids.Semantic proximity Read

Precision Nutrition for Alzheimer's Prevention in ApoE4 Carriers.Semantic proximity Read

Effects of APOE Genotype and Western Diet on Metabolic Phenotypes in Female MiceSemantic proximity Read

Central and Peripheral Mechanisms in ApoE4-Driven Diabetic Pathology.Semantic proximity Read

High-Fat Diet Changes Hippocampal Apolipoprotein E (ApoE) in a Genotype- and Carbohydrate-Dependent Manner in Mice.Semantic proximity Read

APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction.Semantic proximity Read

Sex Differences in Metabolic Indices and Chronic Neuroinflammation in Response to Prolonged High-Fat Diet in ApoE4 Knock-In MiceSemantic proximity Read

In Vivo Effects of ApoE and Clusterin on Amyloid-β Metabolism and NeuropathologySemantic proximity Read