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Article

Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss

5 Sept 2018

Abstract excerpt

Advanced age-related macular degeneration (AMD), the leading cause of blindness among people over 50 years of age, is characterized by atrophic neurodegeneration or pathologic angiogenesis. Early AMD is characterized by extracellular cholesterol-rich deposits underneath the retinal pigment epithelium (RPE) called drusen or in the subretinal space called subretinal drusenoid deposits (SDD) that drive disease...

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Share to Cholesterol and Lipid Metabolism
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PMID: 30185655
DOI: 10.1172/jci.insight.120824

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