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Article

Studies of ApoD-/- and ApoD-/-ApoE-/- mice uncover the APOD significance for retinal metabolism, function, and status of chorioretinal blood vessels.

Cellular and molecular life sciences : CMLS - 1 Feb 2021

El-Darzi Nicole, Mast Natalia, Petrov Alexey M, Dao Tung, Astafev Artem A, Saadane Aicha, Prendergast Erin, Schwarz Emmy, Bederman Ilya, Pikuleva Irina A

Abstract excerpt

Apolipoprotein D (APOD) is an atypical apolipoprotein with unknown significance for retinal structure and function. Conversely, apolipoprotein E (APOE) is a typical apolipoprotein with established roles in retinal cholesterol transport. Herein, we immunolocalized APOD to the photoreceptor inner segments and conducted ophthalmic characterizations of ApoD-/- and ApoD-/-ApoE-/- mice. ApoD-/- mice had normal levels...

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Source

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Identifiers

PMID: 32440710
DOI: 10.1007/s00018-020-03546-3
PMCID: PMC7679289

Genes

APOD
APOE
CD36

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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