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Article

Treating Bietti crystalline dystrophy in a high-fat diet-exacerbated murine model using gene therapy.

Gene therapy - 1 Aug 2020

Qu Bin, Wu Shijing, Jiao Guanyi, Zou Xuan, Li Zhikun, Guo Lu, Sun Xuehan, Huang Cheng, Sun Zixi, Zhang Ying, Li Hui, Zhou Qi, Sui Ruifang, Li Wei

Abstract excerpt

Lipid metabolic deficiencies are associated with many genetic disorders. Bietti crystalline dystrophy (BCD), a blindness-causing inherited disorder with changed lipid profiles, is more common in Chinese and Japanese than other populations. Our results reveal that mouse models lacking Cyp4v3 have less physiological and functional changes than those of BCD patients with this gene defect. After the administration of...

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Share to Corneal Dystrophies, Hereditary
Share to Cytochrome P450 Family 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Disease Models, Animal

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Source

Identifiers

PMID: 32483213
DOI: 10.1038/s41434-020-0159-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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