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Cholesterol crystal formation is a unifying pathogenic mechanism in the development of diabetic retinopathy

14 Jun 2023

Abstract excerpt

Abstract Aims/hypothesis Hyper-reflective crystalline deposits found in retinal lesions have been suggested to predict the progression of diabetic retinopathy, but the nature of these structures remains unknown. Methods Scanning electron microscopy and immunohistochemistry were used to identify cholesterol crystals (CCs) in human donor, pig and mouse tissue. The effects of CCs were analysed in bovine retinal...

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PMID: 37311879
DOI: 10.1007/s00125-023-05949-w

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