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Article

Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration.

Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2005

Malek G, Johnson L V, Mace B E, Saloupis P, Schmechel D E, Rickman D W, Toth C A, Sullivan P M, Bowes Rickman C

Abstract excerpt

Age-related macular degeneration (AMD) is a late-onset, multifactorial, neurodegenerative disease of the retina and the leading cause of irreversible vision loss in the elderly in the Western world. We describe here a murine model that combines three known AMD risk factors: advanced age, high fat cholesterol-rich (HF-C) diet, and apolipoprotein E (apoE) genotype. Eyes of aged, targeted replacement mice expressing...

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Identifiers

PMID: 16079201
DOI: 10.1073/pnas.0503015102
PMCID: PMC1187976

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