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Article

Genetic impacts on within-pair DNA methylation variance in monozygotic twins capture gene-environment interactions and cell-type effects.

Genome biology - 7 Feb 2026

Zhang Xiaopu, Yet Idil, Villicaña Sergio, Castillo-Fernandez Juan, Mangino Massimo, Hottenga Jouke Jan, Tsai Pei-Chien, Min Josine L, Falchi Mario, Wong Andrew, Boomsma Dorret I, Ong Ken K, van Dongen Jenny, Bell Jordana T

Abstract excerpt

BACKGROUND: Genetic variants that are associated with phenotypic variability, or variance quantitative trait loci (vQTLs), have been detected for multiple human traits. Gene-environment interactions can lead to differential phenotypic variability across genotype groups, therefore, genetic variants that interact with environmental exposures can manifest as vQTLs. Although changes in DNA methylation variability...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41654882
DOI: 10.1186/s13059-026-03947-w
PMCID: PMC12977833

Genes

CSGALNACT1
NAPRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

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