Article
Population whole-genome bisulfite sequencing across two tissues highlights the environment as the principal source of human methylome variation.
Genome biology - 23 Dec 2015
Busche Stephan, Shao Xiaojian, Caron Maxime, Kwan Tony, Allum Fiona, Cheung Warren A, Ge Bing, Westfall Susan, Simon Marie-Michelle, Barrett Amy, Bell Jordana T, McCarthy Mark I, Deloukas Panos, Blanchette Mathieu, Bourque Guillaume, Spector Timothy D, Lathrop Mark, Pastinen Tomi, Grundberg Elin
Abstract excerpt
BACKGROUND: CpG methylation variation is involved in human trait formation and disease susceptibility. Analyses within populations have been biased towards CpG-dense regions through the application of targeted arrays. We generate whole-genome bisulfite sequencing data for approximately 30 adipose and blood samples from monozygotic and dizygotic twins for the characterization of non-genetic and genetic effects at...
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