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Article

Genetic impacts on DNA methylation help elucidate regulatory genomic processes.

Genome biology - 31 Jul 2023

Villicaña Sergio, Castillo-Fernandez Juan, Hannon Eilis, Christiansen Colette, Tsai Pei-Chien, Maddock Jane, Kuh Diana, Suderman Matthew, Power Christine, Relton Caroline, Ploubidis George, Wong Andrew, Hardy Rebecca, Goodman Alissa, Ong Ken K, Bell Jordana T

Abstract excerpt

BACKGROUND: Pinpointing genetic impacts on DNA methylation can improve our understanding of pathways that underlie gene regulation and disease risk. RESULTS: We report heritability and methylation quantitative trait locus (meQTL) analysis at 724,499 CpGs profiled with the Illumina Infinium MethylationEPIC array in 2358 blood samples from three UK cohorts. Methylation levels at 34.2% of CpGs are affected by SNPs,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37525248
DOI: 10.1186/s13059-023-03011-x
PMCID: PMC10391992

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