Article

Genetic impacts on DNA methylation help elucidate regulatory genomic processes

2023-04-01

Abstract excerpt

Pinpointing genetic impacts on DNA methylation can improve our understanding of pathways that underlie gene regulation and disease risk. We report heritability and methylation quantitative trait locus (meQTL) analysis at 724,499 CpGs profiled with the Illumina Infinium MethylationEPIC array in 2,358 blood samples from three UK cohorts, with replication. Methylation levels at 34.2% of CpGs were affected by SNPs, an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e286731c-bbf3-5681-8905-c81f7f15e185
DOI: 10.1101/2023.03.31.535045

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic impacts on DNA methylation help elucidate regulatory genomic processesDOI 10.1101/2023.03.31.535045Read

Genetic impacts on DNA methylation help elucidate regulatory genomic processes.Semantic proximity Read

Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.Semantic proximity Read

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation.Semantic proximity Read

Genetic impacts on DNA methylation: research findings and future perspectives.Semantic proximity Read

Disease variants alter transcription factor levels and methylation of their binding sitesSemantic proximity Read

Genomic and phenomic insights from an atlas of genetic effects on DNA methylationSemantic proximity Read

Allele-specific methylation occurs at genetic variants associated with complex disease.Semantic proximity Read

Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era.Semantic proximity Read

Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits.Semantic proximity Read

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inferenceSemantic proximity Read

Uncovering methylation-dependent genetic effects on regulatory element function in diverse genomes.Semantic proximity Read

Genetic control of DNA methylation is largely shared across European and East Asian populations.Semantic proximity Read