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Exploring the Interaction of APOE- <i>ε</i> 4 and PICALM rs3851179 With Dynamic Functional Connectivity in Healthy Middle-Aged Adults at Risk for Alzheimer’s Disease

2025-12-18

Abstract excerpt

<h4>Objective</h4> This study investigates whether dynamic functional connectivity (dFC) dwell-time patterns derived from resting-state fMRI (rs-fMRI) can distinguish Alzheimer’s disease (AD) genetic risk profiles, specifically the APOE - ε 4 (A+) and PICALM rs3851179 (P+) variants, in cognitively healthy, middle-aged adults. <h4>Approach</h4> We estimated recurring dFC clusters from rs-fMRI data and quantif...

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Literature Corpus work
1fb95ee4-c731-5d8f-afda-973ea2ee0b4c
DOI
10.64898/2025.12.16.693545
Open publication

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