Article

Disrupted dynamics of brain structure–function coupling link genetic risk of Alzheimer’s Disease and aging to cognitive decline in 34,067 adults

2026-01-07

Abstract excerpt

<h4> Abstract </h4> Understanding how a stable structural connectome supports flexible cognition, especially in aging, is a fundamental question in neuroscience. While static structure–function coupling (SFC) is well-studied, the dynamic decoupling of functional activity from structural constraints—dynamic SFC (DSFC)—remains poorly understood. Leveraging MRI data from 34,067 UK Biobank participants (ages 45–82),...

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Literature Corpus work: 71db66f6-ea49-5e91-a282-a5bf35bbaf6e
DOI: 10.64898/2026.01.06.697897

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