Exploring the interaction of APOE-ε4and PICALM rs3851179 with dynamic functional connectivity in healthy middle-aged adults at risk for Alzheimer's disease.

doi:10.1088/1741-2552/ae4926

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Article

Exploring the interaction of APOE-ε4and PICALM rs3851179 with dynamic functional connectivity in healthy middle-aged adults at risk for Alzheimer's disease.

Journal of neural engineering - 30 Mar 2026

Dharia Shyamal Y, Valderrama Camilo E, Liu Qian, Smith Stephen D

Abstract excerpt

Objective.This study investigates whether dynamic functional connectivity (dFC) dwell-time patterns derived from resting-state functional magnetic resonance imaging (rs-fMRI) can distinguish Alzheimer's disease (AD) genetic risk profiles, specifically the APOE-ε4(A+) and phosphatidylinositol-binding clathrin assembly protein rs3851179 (P+) variants, in cognitively healthy, middle-aged adults.Approach.We estimated...

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Identifiers

PMID: 41730245
DOI: 10.1088/1741-2552/ae4926

Genes

APOE
PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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