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Article

ABCA7 polymorphisms correlate with memory impairment and default mode network in patients with APOEε4-associated Alzheimer's disease.

Alzheimer's research & therapy - 12 Dec 2019

Chang Ya-Ting, Hsu Shih-Wei, Huang Shu-Hua, Huang Chi-Wei, Chang Wen-Neng, Lien Chia-Yi, Lee Jun-Jun, Lee Chen-Chang, Chang Chiung-Chih

Abstract excerpt

BACKGROUND: Since both APOE and ABCA7 protein expression may independently reduce neuritic plaque burden and reorganize fibrillar amyloid burden-mediated disruption of functional connectivity in the default mode network, we aimed to investigate the effect of the APOE-ABCA7 interaction on default mode network in Alzheimer's disease. METHODS: Two hundred and eighty-seven individuals with a diagnosis of typical...

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PMID: 31831047
DOI: 10.1186/s13195-019-0563-3
PMCID: PMC6909474

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