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Improved overall survival after contralateral risk-reducing mastectomy in BRCA1/2 mutation carriers with a history of unilateral breast cancer: a prospective analysis.

International journal of cancer - 1 Feb 2015

Heemskerk-Gerritsen Bernadette A M, Rookus Matti A, Aalfs Cora M, Ausems Margreet G E M, Collée Johanna M, Jansen Liesbeth, Kets C Marleen, Keymeulen Kristien B M I, Koppert Linetta B, Meijers-Heijboer Hanne E J, Mooij Thea M, Tollenaar Rob A E M, Vasen Hans F A, Hooning Maartje J, Seynaeve Caroline

Abstract excerpt

Data on survival of BRCA1/2-associated primary breast cancer (PBC) patients who opt for subsequent contralateral risk-reducing mastectomy (CRRM) are scarce and inconsistent. We examined the efficacy of CRRM on overall survival in mutation carriers with a history of PBC. From a Dutch multicentre cohort, we selected 583 BRCA-associated PBC patients, being diagnosed between 1980 and 2011. Over time, 242 patients...

Topics

Adult
Aged
Aged, 80 and over
Breast Neoplasms
Female
Genes, BRCA1
Genes, BRCA2
Humans
Mastectomy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Prospective Studies

Source

Identifiers

PMID: 24947112
DOI: 10.1002/ijc.29032

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Improved overall survival after contralateral risk-reducing mastectomy in BRCA1/2 mutation carriers with a history of unilateral breast cancer: a prospective analysis.PMID 24947112Read ↗

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