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Article

Depression-resistant Phenotype in Mice Overexpressing Regulator of G Protein Signaling 8 (RGS8).

Neuroscience - 15 Jul 2018

Kobayashi Yuki, Takemoto Risa, Yamato Shogo, Okada Tomoya, Iijima Michihiko, Uematsu Yoshikatsu, Chaki Shigeyuki, Saito Yumiko

Abstract excerpt

Regulator of G protein signaling (RGS) proteins are negative regulators of heterotrimeric G proteins that act by accelerating Gα-mediated GTPase activity to terminate G protein-coupled receptor-associated signaling. RGS8 is expressed in several brain regions involved with movement and mood. To investigate the role of RGS8 in vivo, we generated transgenic mice overexpressing brain RGS8 (RGS8tg). RGS8 gene and...

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Share to CA1 Region, Hippocampal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Somatostatin

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Source

Identifiers

PMID: 29758252
DOI: 10.1016/j.neuroscience.2018.05.005

Genes

RGS8
MCHR1
FST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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