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Article

Blocking Metabotropic Glutamate Receptor Subtype 7 via the Venus Flytrap Domain Promotes a Chronic Stress-Resilient Phenotype in Mice.

Cells - 2 Jun 2022

Estrela Karolyne A R, Senninger Lisa, Arndt Josephine, Kabas Melanie, Schmid Ferdinand, Dillmann Larissa, Auer Sophia, Stepfer Thomas, Flor Peter J, Uschold-Schmidt Nicole

Abstract excerpt

Chronic psychosocial stress participates prominently in the etiology of various psychiatric conditions and comorbid somatic pathologies; however, suitable pharmacotherapy of these disorders is still of high medical need. During the last few decades, research on mGlu receptors advanced remarkably and much attention was given to the mGlu7 subtype. Here, genetic mGlu7 ablation, short-term pharmacological mGlu7...

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Identifiers

PMID: 35681512
DOI: 10.3390/cells11111817
PMCID: PMC9180111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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