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Article

Genetic determinants of heart failure susceptibility and response in the collaborative cross mouse population.

Genetics - 6 May 2026

Kimball Todd H, Luu Anh N, Gural Brian, Lahue Caitlin, Hockett Abigail, Ravindran Sriram, Ali Amira, Dalal Aryan, Ardery Sam, Sipko Emily L, Kirkland Logan G, Goyal Mansi, Jensen Brian C, Berlow Rebecca B, Rau Christoph D

Abstract excerpt

Genetic variation and lived experiences shape how our hearts respond to chronic stress and development of heart failure, manifested as compromised pumping function and abnormal hemodynamics. The hallmark of heart failure etiology is excessive stress signals followed by maladaptive structural, electrical, and functional changes to the heart muscle, also known as cardiac remodeling. The specific genetic mechanisms...

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Share to Adrenergic beta-Agonists
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Heart Failure

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Share to Myocytes, Cardiac

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Identifiers

PMID: 41617363
DOI: 10.1093/genetics/iyag028
PMCID: PMC13147535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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