Article

Genetic Architecture of Heart Mitochondrial Proteome influencing Cardiac Hypertrophy

2022-08-26

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondria play a key role in the normal function of the heart as well as in the pathogenesis of diseases. We report analysis of common genetic variations contributing to mitochondrial and heart functions using an integrative proteomics approach in a panel of inbred mouse strains called the Hybrid Mouse Diversity Panel (HMDP). We performed a whole heart proteomic analysis in the HMDP (72 strai...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7422d744-eacb-5452-9146-835de445e417
DOI: 10.1101/2022.08.24.505177

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic Architecture of Heart Mitochondrial Proteome influencing Cardiac HypertrophyDOI 10.1101/2022.08.24.505177Read

Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophySemantic proximity Read

Genetic determinants of heart failure susceptibility and response in the collaborative cross mouse population.Semantic proximity Read

A personalized, multi-omics approach identifies genes involved in cardiac hypertrophy and heart failureSemantic proximity Read

Genetic Determinants of Heart Failure Susceptibility and Response in the Collaborative Cross Mouse PopulationSemantic proximity Read

A systems genetics approach to uncover mitochondrial drivers of heart failure reveals mitochondria-nuclear cross talk in genetically diverse mouse strainsSemantic proximity Read

Lipid metabolism drives allele-specific early-stage hypertrophic cardiomyopathySemantic proximity Read

The Genetic Architecture of Dietary Iron Overload and Associated Pathology in MiceSemantic proximity Read

A cross-species multimodal database of gene expression in cardiac hypertrophySemantic proximity Read

Variable outcomes of human heart attack recapitulated in genetically diverse miceSemantic proximity Read

Systems proteomics of liver mitochondria function.Semantic proximity Read

Shared and Divergent Features of Cardiac Transcriptome and Glucose Metabolism Markers in Human and Mouse HFpEFSemantic proximity Read

Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respirationSemantic proximity Read