Article

A personalized, multi-omics approach identifies genes involved in cardiac hypertrophy and heart failure

2017-03-24

Abstract excerpt

Identifying genes underlying complex diseases remains a major challenge. Biomarkers are typically identified by comparing average levels of gene expression in populations of healthy and diseased individuals. However, genetic diversities may undermine the effort to uncover genes with significant but individual contribution to the spectrum of disease phenotypes within a population. Here we leverage the Hybrid Mouse...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 242f72f7-bed4-545f-a4d4-2c5ad4c725c6
DOI: 10.1101/120329

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A personalized, multi-omics approach identifies genes involved in cardiac hypertrophy and heart failureDOI 10.1101/120329Read

Relationship of disease-associated gene expression to cardiac phenotype is buffered by genetic diversity and chromatin regulation.Semantic proximity Read

Genetic determinants of heart failure susceptibility and response in the collaborative cross mouse population.Semantic proximity Read

Genetic Determinants of Heart Failure Susceptibility and Response in the Collaborative Cross Mouse PopulationSemantic proximity Read

Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in MiceSemantic proximity Read

Genetic Architecture of Heart Mitochondrial Proteome influencing Cardiac HypertrophySemantic proximity Read

Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse ModelSemantic proximity Read

Mapping DNA Methylation to Cardiac Pathologies Induced by Beta-Adrenergic Stimulation in a Large Panel of MiceSemantic proximity Read

Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophySemantic proximity Read

A cross-species multimodal database of gene expression in cardiac hypertrophySemantic proximity Read

Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans.Semantic proximity Read

Involvement of human monogenic cardiomyopathy genes in experimental polygenic cardiac hypertrophy.Semantic proximity Read

Integrative genetic and network approaches to identify key regulators of cardiac fibrosisSemantic proximity Read