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Article

Variable outcomes of human heart attack recapitulated in genetically diverse mice

4 Mar 2019

Abstract excerpt

Clinical variation in patient responses to myocardial infarction (MI) has been difficult to model in laboratory animals. To assess the genetic basis of variation in outcomes after heart attack, we characterized responses to acute MI in the Collaborative Cross (CC), a multi-parental panel of genetically diverse mouse strains. Striking differences in post-MI functional, morphological, and myocardial scar features...

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PMID: 30854227
DOI: 10.1038/s41536-019-0067-6

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