Article

A systems genetics approach to uncover mitochondrial drivers of heart failure reveals mitochondria-nuclear cross talk in genetically diverse mouse strains

2025-12-15

Abstract excerpt

The contribution of mitochondrial genetics to heart failure is thought to be reciprocal. Its complex traits are influenced by genetic and environmental factors. Genetically diverse mouse strains form a vital repository to uncover the interaction between the mitochondrial and nuclear genomes underlying heart failure due to their traceable genetic origins, maternal lineages and controlled genetic variation. Using sy...

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Literature Corpus work: b28909da-6f2c-57e7-8226-3d6325929d17
DOI: 10.64898/2025.12.12.693865

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