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Article

Beyond predictive R2: Quantile regression and non-equivalence tests reveal complex relationships of traits and polygenic scores.

American journal of human genetics - 5 Jun 2025

Mefford Joel, Smullen Molly, Zhang Felix, Sadowski Michal, Border Richard, Dahl Andy, Flint Jonathan, Zaitlen Noah

Abstract excerpt

Polygenic scores (PGSs) are genetic predictions of trait values or disease risk that are increasingly finding applications in clinical predictive models and basic genetics research. However, the predictive value of a PGS can vary within similar population groups, depending on characteristics such as the environmental exposures, sex, age, or socioeconomic status of the individuals. To maximize the value of a PGS,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40480198
DOI: 10.1016/j.ajhg.2025.04.013
PMCID: PMC12256909

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