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Article

Population pharmacokinetics of isoniazid and dose recommendations in Mexican patients with tuberculosis.

International journal of clinical pharmacy - 1 Aug 2020

Huerta-García Ana Patricia, Medellín-Garibay Susanna Edith, Ortiz-Álvarez Arturo, Magaña-Aquino Martín, Rodríguez-Pinal Cristian Jazmín, Portales-Pérez Diana Patricia, Romano-Moreno Silvia, Milán-Segovia Rosa Del Carmen

Abstract excerpt

Background The standardized doses of isoniazid in therapy against tuberculosis are determined based on total body weight, without considering genetic polymorphisms of the metabolic enzyme N-acetyltransferase-2 that contribute to the wide pharmacokinetic variability of isoniazid. Objective The aim of this work was to build a population pharmacokinetic model of isoniazid in Mexican patients with tuberculosis to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromatography, High Pressure Liquid

Share to Dose-Response Relationship, Drug

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Identifiers

PMID: 32638292
DOI: 10.1007/s11096-020-01086-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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