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Article

A method for an unbiased estimate of cross-ancestry genetic correlation using individual-level data.

Nature communications - 9 Feb 2023

Momin Md Moksedul, Shin Jisu, Lee Soohyun, Truong Buu, Benyamin Beben, Lee S Hong

Abstract excerpt

Cross-ancestry genetic correlation is an important parameter to understand the genetic relationship between two ancestry groups. However, existing methods cannot properly account for ancestry-specific genetic architecture, which is diverse across ancestries, producing biased estimates of cross-ancestry genetic correlation. Here, we present a method to construct a genomic relationship matrix (GRM) that can...

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Identifiers

PMID: 36759513
DOI: 10.1038/s41467-023-36281-x
PMCID: PMC9911789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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