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From Genotype to Phased Haplotype: Multiplex Digital PCR-Based Haplotyping at the APOE Locus in Alzheimer’s Disease

2025-09-30

Abstract excerpt

<title>Abstract</title> <p>Backgrounds: Alzheimer’s disease (AD) risk reflects multi-locus variant effects. Despite advances in genotyping techniques, current molecular haplotyping approaches involve intricate operational frameworks and incur high implementation costs, and most studies therefore rely on unphased genotypes. We developed a straightforward approach to reconstruct locus-wide haplotype structure withi...

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Literature Corpus work
c4e2000e-a25f-5cc3-94a6-b82c28fd4819
DOI
10.21203/rs.3.rs-7634101/v1
Open publication

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From Genotype to Phased Haplotype: Multiplex Digital PCR-Based Haplotyping at the APOE Locus in Alzheimer’s DiseaseDOI 10.21203/rs.3.rs-7634101/v1
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