Article
Endothelial oncogenic KRAS mutation drives the dynamics of microglia and macrophages in brain arteriovenous malformation.
JCI insight - 23 Mar 2026
Park Hyejin, Park Jung-Eun, Freeman Bridger H, Yang Bosco Seong Kyu, Ting Shun-Ming, Suh Alexander K, Savarraj Jude Pj, Huang Shuning, Körbelin Jakob, Choi Huimahn Alex, Marrelli Sean P, Aronowski Jaroslaw, Chen Peng Roc, Kim Eunhee, Park Eun S
Abstract excerpt
Mutation of KRAS in endothelial cells (KRAS-ECs) leads to intracerebral hemorrhage (ICH) in brain arteriovenous malformation (bAVM), resulting in severe disabilities or even death. However, it is unclear what causes this hemorrhagic conversion of bAVMs. Here, using a locally established, clinically relevant sporadic bAVM mouse model, created by overexpressing mutant KRAS (KRASG12V) in brain ECs, we demonstrate...
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