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Article

Endothelial k-RasV12 Expression Induces Capillary Deficiency Attributable to Marked Tube Network Expansion Coupled to Reduced Pericytes and Basement Membranes.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2022

Sun Zheying, Kemp Scott S, Lin Prisca K, Aguera Kalia N, Davis George E

Abstract excerpt

OBJECTIVE: We sought to determine how endothelial cell (EC) expression of the activating k-Ras (kirsten rat sarcoma 2 viral oncogene homolog) mutation, k-RasV12, affects their ability to form lumens and tubes and interact with pericytes during capillary assembly Approach and Results: Using defined bioassays where human ECs undergo observable tubulogenesis, sprouting behavior, pericyte recruitment to EC-lined...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34879709
DOI: 10.1161/ATVBAHA.121.316798
PMCID: PMC8792373

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