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Article

Selective Endothelial Hyperactivation of Oncogenic KRAS Induces Brain Arteriovenous Malformations in Mice.

Annals of neurology - 1 May 2021

Park Eun S, Kim Sehee, Huang Shuning, Yoo Ji Young, Körbelin Jakob, Lee Tae Jin, Kaur Balveen, Dash Pramod K, Chen Peng R, Kim Eunhee

Abstract excerpt

OBJECTIVE: Brain arteriovenous malformations (bAVMs) are a leading cause of hemorrhagic stroke and neurological deficits in children and young adults, however, no pharmacological intervention is available to treat these patients. Although more than 95% of bAVMs are sporadic without family history, the pathogenesis of sporadic bAVMs is largely unknown, which may account for the lack of therapeutic options. KRAS...

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PMID: 33675084
DOI: 10.1002/ana.26059

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