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Article

Mutant KRAS in brain endothelial cells promotes vascular inflammation and impairs vascular integrity in brain arteriovenous malformation.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Jul 2026

Park Jung-Eun, Freeman Bridger H, Park Hyejin, Kim Sehee, Bafor Adrian E, Myint Ohnmar, Gao Song, Xu Zhen, Körbelin Jakob, Aronowski Jaroslaw, Chen Peng Roc, Kim Eunhee, Park Eun S

Abstract excerpt

Somatic KRAS (KRASG12V) mutation in endothelial cells (EC) induces brain arteriovenous malformation (bAVM) that could lead to vascular instability and ultimately bleeding. However, the causes of bAVM instability remain unclear. Here we demonstrate that KRASG12V expressing cultured ECs (KRAS-G12V-EC) have increased expression of pro-inflammatory mediators and reduced expression of blood-brain-barrier (BBB)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41696778
DOI: 10.1177/0271678X261421424
PMCID: PMC12913046

Genes

KRAS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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