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Article

Dual MAPK/VEGF inhibition for KRAS-mutated brain arteriovenous malformations.

Journal of neurosurgery - 1 Feb 2026

Naylor Ryan M, Ueki Yasuhito, Alsereidi Fatmah R, Bektas Delal, Haugen Anna, Kadirvel Ram

Abstract excerpt

OBJECTIVE: Brain arteriovenous malformations (bAVMs) are rare but potentially devastating cerebrovascular lesions. Activating KRAS mutations are common in sporadic bAVMs, but their clinical implications remain unclear. The aim of this study was to investigate a novel therapeutic strategy for hemorrhagic bAVMs based on dual inhibition of the mitogen-activated protein kinase (MAPK) and vascular endothelial growth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41172372
DOI: 10.3171/2025.7.JNS25708

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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