Article
Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria.
BMC genetics - 6 Aug 2011
Ong'echa John M, Raballah Evans O, Kempaiah Prakasha M, Anyona Samuel B, Were Tom, Davenport Gregory C, Konah Stephen, Vulule John M, Ouma Collins, Hittner James B, Perkins Douglas J
Abstract excerpt
BACKGROUND: Plasmodium falciparum malaria remains a leading cause of morbidity and mortality among African children. Innate immunity provides the first line of defence against P. falciparum infections, particularly in young children that lack naturally-acquired malarial immunity, such as the population examined here. Consistent with the fact that elevated interleukin (IL)-12 is an important component of the...
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