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Article

OSBPL10, RXRA and lipid metabolism confer African-ancestry protection against dengue haemorrhagic fever in admixed Cubans.

PLoS pathogens - 1 Feb 2017

Sierra Beatriz, Triska Petr, Soares Pedro, Garcia Gissel, Perez Ana B, Aguirre Eglys, Oliveira Marisa, Cavadas Bruno, Regnault Béatrice, Alvarez Mayling, Ruiz Didye, Samuels David C, Sakuntabhai Anavaj, Pereira Luisa, Guzman Maria G

Abstract excerpt

Ethnic groups can display differential genetic susceptibility to infectious diseases. The arthropod-born viral dengue disease is one such disease, with empirical and limited genetic evidence showing that African ancestry may be protective against the haemorrhagic phenotype. Global ancestry analysis based on high-throughput genotyping in admixed populations can be used to test this hypothesis, while admixture...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28241052
DOI: 10.1371/journal.ppat.1006220
PMCID: PMC5344536

Genes

OSBPL10
RXRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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