Evaluating the Causal Link Between Malaria Infection and Endemic Burkitt Lymphoma in Northern Uganda: A Mendelian Randomization Study.

doi:10.1016/j.ebiom.2017.09.037

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Article

Evaluating the Causal Link Between Malaria Infection and Endemic Burkitt Lymphoma in Northern Uganda: A Mendelian Randomization Study.

EBioMedicine - 1 Nov 2017

Legason Ismail D, Pfeiffer Ruth M, Udquim Krizia-Ivana, Bergen Andrew W, Gouveia Mateus H, Kirimunda Samuel, Otim Isaac, Karlins Eric, Kerchan Patrick, Nabalende Hadijah, Bayanjargal Ariunaa, Emmanuel Benjamin, Kagwa Paul, Talisuna Ambrose O, Bhatia Kishor, Yeager Meredith, Biggar Robert J, Ayers Leona W, Reynolds Steven J, Goedert James J, Ogwang Martin D, Fraumeni Joseph F, Prokunina-Olsson Ludmila, Mbulaiteye Sam M

Abstract excerpt

BACKGROUND: Plasmodium falciparum (Pf) malaria infection is suspected to cause endemic Burkitt Lymphoma (eBL), but the evidence remains unsettled. An inverse relationship between sickle cell trait (SCT) and eBL, which supports that between malaria and eBL, has been reported before, but in small studies with low power. We investigated this hypothesis in children in a population-based study in northern Uganda using...

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Identifiers

PMID: 29033373
DOI: 10.1016/j.ebiom.2017.09.037
PMCID: PMC5704046

Genes

SCT
IFNAR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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