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Article

Integrative genomic analysis reveals mechanisms of immune evasion in P. falciparum malaria.

Nature communications - 9 Oct 2020

Dieng Mame Massar, Diawara Aïssatou, Manikandan Vinu, Tamim El Jarkass Hala, Sermé Samuel Sindié, Sombié Salif, Barry Aïssata, Coulibaly Sam Aboubacar, Diarra Amidou, Drou Nizar, Arnoux Marc, Yousif Ayman, Tiono Alfred B, Sirima Sodiomon B, Soulama Issiaka, Idaghdour Youssef

Abstract excerpt

The mechanisms behind the ability of Plasmodium falciparum to evade host immune system are poorly understood and are a major roadblock in achieving malaria elimination. Here, we use integrative genomic profiling and a longitudinal pediatric cohort in Burkina Faso to demonstrate the role of post-transcriptional regulation in host immune response in malaria. We report a strong signature of miRNA expression...

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Identifiers

PMID: 33037226
DOI: 10.1038/s41467-020-18915-6
PMCID: PMC7547729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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