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Article

CRM1 inhibits NPAT condensation and histone locus body formation via a competitive occupation strategy.

The Journal of cell biology - 2 Feb 2026

Cong Xiao Xia, Xu Shui Bo, Zou Wen Kai, Gao Xiu Kui, Pan Zhao Yuan, Liang Hao Di, Chen Juan, Tao Jia Li, Chen Xu Qi, Chen Rui Jie, Ge Bai Te, Weng Jia Hui, Huang Man, Lu Lin Rong, Zou Xiaohui, Zhou Yi Ting, Zheng Li Ling

Abstract excerpt

Importins could inhibit the condensation of RNA-binding proteins, while it remains unknown whether exportins elicit a similar function. Here, we identified that exportin CRM1 binds to the nuclear protein NPAT, which initiates and maintains the formation of the histone locus body (HLB), a membraneless nuclear body regulating histone transcription. CRM1 drives the nuclear export of NPAT by targeting a nuclear...

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PMID: 41481226
DOI: 10.1083/jcb.202412173

Genes

NPAT
NES

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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