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Inhibiting cancer cell hallmark features through nuclear export inhibition

1 Jul 2016

Abstract excerpt

Treating cancer through inhibition of nuclear export is one of the best examples of basic research translation into clinical application. Nuclear export factor chromosomal region maintenance 1 (CRM1; Xpo1 and exportin-1) controls cellular localization and function of numerous proteins that are critical for the development of many cancer hallmarks. The diverse actions of CRM1 are likely to explain the broad...

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PMID: 29263896
DOI: 10.1038/sigtrans.2016.10

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