Article
RNA-binding protein diversity and NLS arginines regulate FUS mixing in mRNA-rich compartments.
Cell reports - 23 Jun 2026
Valenti Diane, Joshi Vandana, Pankivskyi Serhii, Cai Hoang Hung, Hamon Loic, Desforges Bénédicte, Molliex Amandine, Duez Julien, Bursztyka Julian, Davignon Laurianne, Maucuer Alexandre, Bollot Guillaume, Pastré David
Abstract excerpt
Despite being prone to condensation, many RNA-binding proteins (RBPs) do not form large condensates in cells. This issue is still widely researched, particularly because aggregation of RBPs, such as FUS, is the hallmark of some neurodegenerative diseases. Elevated RNA levels and protein chaperone activity have already emerged as key factors preventing aberrant phase separation. Here, we explored the role of RBP...
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