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Article

Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation.

Molecular cell - 19 Mar 2020

Greig Jamie A, Nguyen Tu Anh, Lee Michelle, Holehouse Alex S, Posey Ammon E, Pappu Rohit V, Jedd Gregory

Abstract excerpt

Low-complexity protein domains promote the formation of various biomolecular condensates. However, in many cases, the precise sequence features governing condensate formation and identity remain unclear. Here, we investigate the role of intrinsically disordered mixed-charge domains (MCDs) in nuclear speckle condensation. Proteins composed exclusively of arginine-aspartic acid dipeptide repeats undergo...

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Identifiers

PMID: 32048997
DOI: 10.1016/j.molcel.2020.01.025
PMCID: PMC10715173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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